Mechanotransduction - Dr. David De Camillis

Effectiveness of an intervention (effleurage and petrissage) on the severity of chemotherapy-induced peripheral neuropathy (CIPN) among patients: A randomized control pilot trial

A nociceptive-nociplastic spectrum of myofascial orofacial pain: insights from neuronal ion channel studies

Cell response to extracellular matrix viscous energy dissipation outweighs high-rigidity sensing

Evidence Supporting Conservative Scar Management Interventions Following Burn Injury: a review article

Modelling and targeting mechanical forces in organ fibrosis

Piezo1: the key regulators in central nervous system disease

Stiffening symphony of aging: Biophysical changes in senescent osteocytes

Mechanomodulation: Physical Treatment Modalities Employ Mechanotransduction to Improve Scarring

Cellular and Nuclear Forces: An Overview

Tension at the gate: sensing mechanical forces at the blood-brain barrier in health and disease

Macrophages regulate angiogenesis-osteogenesis coupling induced by mechanical loading through the Piezo1 pathway

Activation of connexin hemichannels enhances mechanosensitivity and anabolism in disused and aged bone

Tension-sensitive HOX gene expression in fibroblasts for differential scar formation

Biomechanical properties of ovarian tissue and their impact on the activation of follicular growth: a narrative review

Non-Newtonian lacuno-canalicular fluid flow in bone altered by mechanical loading and magnetic field

Dynamically changing extracellular matrix stiffness drives Schwann cell phenotype

Mitochondria mechanosensing: The powerhouse fueling cellular force signaling

Nuclear envelope components in vascular mechanotransduction: emerging roles in vascular health and disease

Experimental tools and emerging principles of organellar mechanotransduction

Protein prenylation in mechanotransduction: implications for disease and therapy

The role of vascular and lymphatic networks in bone and joint homeostasis and pathology

The Role of Mechanosensitive Piezo Channels in Chronic Pain

Macrophages regulate angiogenesis-osteogenesis coupling induced by mechanical loading through the Piezo1 pathway

Cellular and Nuclear Forces: An Overview

Tension at the gate: sensing mechanical forces at the blood-brain barrier in health and disease

A network of trans-cortical capillaries as mainstay for blood circulation in long bones

Focus on mechano-immunology: new direction in cancer treatment

Nuclear envelope components in vascular mechanotransduction: emerging roles in vascular health and disease

Mitochondria mechanosensing: The powerhouse fueling cellular force signaling

Dynamically changing extracellular matrix stiffness drives Schwann cell phenotype

Non-Newtonian lacuno-canalicular fluid flow in bone altered by mechanical loading and magnetic field

Role of YAP/TAZ in bone diseases: A transductor from mechanics to biology

The LINC complex in blood vessels: from physiology to pathological implications in arterioles

Biomechanical properties of ovarian tissue and their impact on the activation of follicular growth: a narrative review

Tension-sensitive HOX gene expression in fibroblasts for differential scar formation

The Evolving Role of PTH Signaling in Osteocytes

Matrix metalloproteinases accelerate pericellular matrix breakdown and disrupt mechanotransduction in osteoarthritis

The relationship between myodural bridge, atrophy and hyperplasia of the suboccipital musculature, and cerebrospinal fluid dynamics

A new analogous organ in bony fishes and amphibians: an anatomical structure related with the cerebrospinal fluid circulation

[Research progress on the role of mechanical stretch in the injury and repair of alveolar epithelial cells]

The emerging roles of the endoplasmic reticulum in mechanosensing and mechanotransduction

Mechanical Stretch Promotes the Migration of Mesenchymal Stem Cells via Piezo1/F-actin/YAP Axis

Piezo proteins, mechano reception and behaviour in Hydra

Mechanically Affected Lung and Progression of Emphysema

Experimental tools and emerging principles of organellar mechanotransduction

Viscoelastic mechanics of living cells

Role of the cytoskeleton in cellular reprogramming: effects of biophysical and biochemical factors

The role of ion channels in the regulation of dendritic cell function

Piezo1 is a Pathogenic Gene and Therapeutic Target for Neurological Diseases

Emerging roles of mechanically activated ion channels in autoimmune disease

Mechanical sensing protein PIEZO1 controls osteoarthritis via glycolysis mediated mesenchymal stem cells-Th17 cells crosstalk

Colorectum and Embedded Networks of Nerve Fibers Present Auxetic Responses During Uniaxial Circumferential Extension

The Role of Connections Between Cellular and Tissue Mechanical Elements and the Importance of Applied Energy in Mechanotransduction in Cancerous Tissue

From fluctuations to stability: In-Situ chondrocyte response to cyclic compressive loading

Pathophysiology and healing of insertional Achilles tendinopathy: Current concepts

The Role of Connections Between Cellular and Tissue Mechanical Elements and the Importance of Applied Energy in Mechanotransduction in Cancerous Tissue

Mechanosensitive Ion Channels: The Unending Riddle of Mechanotransduction

Mechanosignaling in Osteoporosis: When Cells Feel the Force

Mechano-metabolism on the rise

Mechanotransduction and inflammation: An updated comprehensive representation

Ultrasound imaging and regulated mechanotransduction for characteristics, regeneration, and therapeutics of bone

Mechanotransduction in subchondral bone microenvironment and targeted interventions for osteoarthritis

Mechanotransduction in osteoclasts: Novel strategies of bone repairs

Mechanobiology research in China

Effects of different movement velocities during resistance training on bone mineral density in older adults: A systematic review and meta-analysis

Defining Critical Humeral Bone Loss: Inferior Craniocaudal Hill-Sachs Extension as Predictor of Recurrent Instability After Primary Arthroscopic Bankart Repair

Role of Masticatory Force in Modulating Jawbone Immunity and Bone Homeostasis: A Review

The stiffness of extracellular matrix (ECM) in regulating cellular metabolism

ENDOTHELIAL GLYCOCALYX AND ATHEROSCLEROSIS: FROM MOLECULAR MECHANISMS TO THERAPEUTIC OPPORTUNITIES

Acquired Piezo2 Channelopathy is One Principal Gateway to Pathophysiology

Mechanotransduction for therapeutic approaches: Cellular aging and rejuvenation

Leveraging mechanobiology: Identifying mechanotransducers with potential applications for tendon repair

ACL Pacinian mechanoreceptors: Conceptualizing a vasoregulatory microtrauma healing function

Emerging mechanomedicines informed by mechanotransduction along the integrin-cytoskeleton-nucleus axis

The research progress into cellular mechanosensitive ion channels mediating cancer pain

Mechanotransduction as a therapeutic target for brain tumours

Mechanotransduction as a therapeutic target for tumours

GsMTx4-loaded GelMA promotes tendon regeneration and suppresses heterotopic ossification via the Apelin signaling pathway

Aging and Altered Gravity: A Cellular Perspective

Targeting mechanotransduction in osteosarcoma

Ion channels as therapeutic targets in osteoarthritis

The substructure of the endothelial glycocalyx in rat aorta and its interaction with the low-density lipoproteins (LDL)

Mechanosensitive ion channels and inflammation: key links in cellular signal transduction

Rheumatoid hand massage therapy to mitigate sarcopenia and improve patients’ quality of life: a hypothesis

Mechanosensitive Piezo channels in mineralized tissues: emerging roles in osteodental adaptation and disease

Mechanical effects in aging of the musculoskeletal system: Molecular signaling and spatial scale alterations

Shear Stress-Dependent Modulation of Endothelin B Receptor: The Role of Endothelial Glycocalyx Heparan Sulfate

Mechanotransduction: A Master Regulator of Alveolar Cell Fate Determination

Molecular basis of individual locomotor function: Integrated understanding of gene expression regulation in the development and homeostasis of the musculoskeletal system

Osteocytes function as biomechanical signaling hubs bridging mechanical stress sensing and systemic adaptation

Mechanosensitive Ion Channel Piezo Therapy in Digestive Diseases

Targeted elimination of mesenchymal-like cancer cells through cyclic stretch activation of Piezo1 channels: the physical aspects

Mechanobiology in the eye

Mechanistic Interactions Driving Nucleus Pulposus Cell Senescence in Intervertebral Disc Degeneration: A Multi-Axial Perspective of Mechanical, Immune, and Metabolic Pathways

TRPV4 in Cerebral Small Vessel Disease: A key interacting partner

The lateral stress profile of fluid lipid membranes as revealed by the diffuse interface approach

Insights Into the Dysfunctional Communication Switches Targeting Osteocyte Mechanotransduction and Lacunar-Canalicular Gene Network in Pathogenesis of Osteoarthritis

Current status and future direction of mechanotransduction mechanisms: Perspectives from cell membrane to nucleus

Matrix-induced nuclear remodeling and mechano-therapeutics

Breaking Down Osteoarthritis: Exploring Inflammatory and Mechanical Signaling Pathways

PIEZO Channels in Mechano-Inflammation: Gatekeepers of Neuroimmune Crosstalk

Comment on “Mechanotransduction in tumor dynamics modeling”

Mechanical Stimulation Alters Chronic Ethanol-Induced Changes to VTA GABA Neurons, NAc DA Release and Measures of Withdrawal

Mechanical stimulation of cervical vertebrae modulates the discharge activity of ventral tegmental area neurons and dopamine release in the nucleus accumbens

Transient skin stretching stimulates immune surveillance and promotes vaccine delivery via hair follicles

Tendon mechanobiology in the context of tendon biofabrication

Spotlight on membrane fluidity of normal and cancer cells: Implications for cancer diagnosis and treatment

Mechanosensor Piezo1‑mediated smooth muscular cell pyroptosis contributes to vascular calcification

An overview of mechanical microenvironment and mechanotransduction in intervertebral disc degeneration

Obstacles Regulate Membrane Tension Propagation to Enable Localized Mechanotransduction

Mechanotransduction as a therapeutic target in tendinopathy: molecular pathways and exercise implications

PIEZO1: a mechanosensitive ion channel in the pathogenesis and pharmacotherapy of diabetic neuropat

The central mechanotransducer in osteoporosis pathogenesis and therapy

Neurophysiological assessment of bone mechanosensitivity using the bone myoregulation reflex

Twist is the key to the gating of mechanosensitive ion channel NOMPC

Knee Joint Response to Mechanical Loading: Bounding Mechanotransduction with Rehabilitation

Mechanosensitive channel Piezo1 in calcium dynamics: structure, function, and emerging therapeutic strategies

PIEZO1-Primary Cilia Axis Mediates Compressive Stress-Induced Growth Plate Degeneration and Ossification in Adolescent Idiopathic Scoliosis

Non-coding RNAs mediate mechanical load-regulating bone metabolic homeostasis

Exploring fascia in myofascial pain syndrome: an integrative model of mechanisms

Mechanical Vibration-Induced Change in Stiffness of Breast Cancer Cells Promotes Natural Killer Cell-Mediated Tumor Killing Activity

Transient receptor potential channels in chondrocyte homeostasis and pathophysiology: From molecular mechanisms to translational therapeutics

Piezo1 and tissue fibrosis: insights into its role and potential for modulation

Bladder Trigone as a Sensory Hub: A Narrative Review

A Unified Map of Airway Interactions: Secretome and Mechanotransduction Loops from Development to Disease

Piezo1-mediated mechano-energetics regulate CAR T cell function

The Mechanobiological Hypothesis of Piezo Family-Mediated Exercise Intervention in Spinal Cord Injury Recovery

Disturbed flow induces reprogramming of endothelial cells to immune-like and foam cells under hypercholesterolaemia during atherogenesis

Recent Advances in Periodontal Regenerative Medicine: A Focus on the Role of Mechanical Stimulation

New Roles of bZIP-Containing Membrane-Bound Transcription Factors in Chromatin Tethering and Karyoptosis

Mechanotransduction Pathways in Massage Therapy: CB1/Piezo2 Receptor Crosstalk Modulates Myocellular Anti-Inflammatory Responses

Mechanomedicine: Translating mechanical forces into therapeutic strategies

Mechanosensing in Dendritic Cells

The mechanosensitive Piezo channels as potential therapeutic targets for osteoarthritis

Beyond tendon interfaces – Functional divergence of the matricellular protein SPARC

Mechanobiology of Adipose Tissue Remodeling

Mechanoimmunology: past, present, and future perspectives

The emerging role of TRPV4 in skeletal biology: Mechanotransduction, mutation, and therapeutic potential

Acupuncture Mechanics, Stimulation, and Cellular Serotonin Detection by a Magneto-Responsive Nanomesh Sensor

Insights into the role of the mechanosensitive Piezo1 channel and signaling mechanisms in CNS functions and diseases

Neuromechanobiology: Bridging Mechanobiology and Neuroscience Through Evidence and Open Questions

Exercise-Based Mechanotherapy: From Biomechanical Principles and Mechanotransduction to Precision Regenerative Rehabilitation

Extracellular Matrix in Human Disease and Therapy: From Pathogenic Remodeling to Biomaterial Platforms and Precision Diagnostics

The role of TRPV4 in ischemic stroke

Connections between physics and metabolism in brain functions

The brain–bone axis: unraveling the complex interplay between the central nervous system and skeletal metabolism

ECM-Targeted and cell-based therapies in musculoskeletal and aging-related disorders: A review

Abnormal mechanical load aggravates subchondral bone remodeling and uneven tibial plateau settlement in knee osteoarthritis via activation of osteoblast Piezo1-Ca²⁺-JAK2/STAT3 signaling

Biophysical signal-driven scaffold design for stem cell-guided osteochondral regeneration

Blood Mechanical Intelligence: From Force Sensing to Precision Mechanomedicine

Mechanobiology of the Nucleolus

Haptic skin intelligence: Digitizing cutaneous mechanics for investigative dermatology

Estimation of flow-induced deformation of glycocalyx layer on vascular endothelial cells: Comparison of three methods

Lipid Regulation of Mechanosensitive Ion Channels

From mechanosensing to immune regulation: mechanisms of acupuncture signal initiation and amplification mediated by macrophages

Tissue-Resident Macrophage PIEZO1 Transduces Mechanical Stress into Inflammatory Pain in Acute Gout

Targeting the extracellular matrix in precision medicine: opportunities for diagnostics and therapeutics

Mechanical polarity as a driver of bone regeneration: a multiscale framework linking tension, mechanotransduction and cortical apposition

Matrix stiffness and stress relaxation regulate osteogenesis through histone demethylases KDM4B and KDM6B

Distinct P2 receptors initiate intracellular signaling involved in mechanotransduction in tenocytes

Gradient mechanical environments modulate intra-osteonal fluid flow: a three-dimensional finite element study

Mechanotransduction and its impact on regenerative medicine in orthopedic rehabilitation (Review)

Convergent Regenerative Strategies in PM&R for Musculoskeletal and Hair Restoration: Integration of PRP, Exosomes, and Physical Modalities

Modeling and investigating the interactive role of fluid velocity and pore pressure within the lacunar-canalicular system in load-induced osteogenesis

Mechanisms of Mucoid Degeneration in the Cruciate Ligament: Role of Denatured Aggrecan Accumulation and Tissue Dysfunction

Twenty Years Development of Tibial Cortex Transverse Transport Surgery in PR China

A Rat Model of Tibial Cortex Transverse Transport for the Treatment of Lower Limb Ischemia\\

The extracellular matrix: structure, composition, biological functions, diseases, and therapeutic targets

Shear-Calibrated High-Intensity Interval Training to Promote Endothelial Autophagy and Delay Vascular Senescence: A Biomarker-Guided Approac

The Emerging Role of Mechanobiology in Connecting Metabolic and Cardiovascular Diseases: From Fundamentals to Future Therapies

The Degeneration Paradox: Severely Degenerated Cervical Nucleus Pulposus Cells Display Enhanced Mechanoplasticity Under Moderate Cyclic Tensile Strain

Glymphatic dysfunction: a unifying hypothesis for delirium

Piezo2 mediates mechanical sensitivity and injury-induced hypersensitivity in MrgprD-expressing nociceptors

PIEZO1 variants that reduce open channel probability are associated with familial osteoarthritis

Cyclic tensile stress restores chondrocyte homeostasis via integrin-FAK-RhoA/ROCK2 signaling: A multi-omics study

Fluid shear stress activates c-Src and promotes RANKL localization in the plasma membrane in osteoblast-like MC3T3-E1 cells

Hidden Receptor Crosstalk Governs Lymphatic Failure After Cancer Therapy

Flow-sensitive K + channels link flow to piezo1/PI3K/Akt1 pathway

Sensing of shear stress in vascular endothelial cells – from physiology to pathology

Piezo channels in tumors

Association between age-related AGE accumulation and deterioration of canalicular physical properties in a mouse model of senile osteoporosis: Potential implications for osteocyte mechanotransduction

Current perspectives on the etiology and pathogenesis of tendinopathy – a literature review

Osteocyte Cell-Cell Communication Within and Beyond Bone Current Insights into the Molecular Mechanisms of Intracranial Atherosclerosis and Their Therapeutic Implications

Mechanical bone loading effects on morphology and mechanobiology in the coronal suture of Crouzon mice

Bone tissue regeneration: role of osteocyte mechanosensing and mechanotransduction

Piezo2 Mediates a Vicious Cycle of “Mechanical Homeostasis Imbalance-Inflammation” in Sensory Nerves and the Cartilage Endplate

Interplay between extracellular matrix mechanics and cell function in mechanobiology

Transcranial vibrotactile stimulation enhances hippocampal cholinergic signaling and memory through frequency-dependent mechanotransduction

Influence of tissue compliance changes in the Cranio-cervical junction on cerebrospinal fluid dynamics

Tumor microenvironment and mechanotransduction pathways: Novel targets and new directions for cancer therapy

Medium-term recovery of patients with complex lower limb fractures : follow-up study of fracture types in the Wound Healing in Surgery for Trauma (WHIST) trial

Meniscus Root Repairs Are Associated With High Rates of Postoperative Deep Vein Thrombosis

Extracellular Matrix Signaling Cues: Biological Functions, Diseases, and Therapeutic Targets

Piezo2 in Mechanosensory Biology: From Physiological Homeostasis to Disease-Promoting Mechanisms

Mechanoglycobiology: The Roles of Cell Surface Glycans in Mechanosensing and Mechanotransduction

Voltage-gated sodium channels: Mechanisms, disease, and a growing research community